deauville score hodgkin lymphoma
Therefore, this study aimed to explore if radiomic features from NECT images are linked to the metabolic activity of Hodgkin lymphoma manifestations and can discriminate between DS4-negative (DS 13) and DS4-positive (DS4 and DS5) manifestations. Context: Positron emission tomography (PET) using F-18 fluorodeoxyglucose (FDG) for treatment monitoring in patients with lymphoma is one of the most well-developed clinical applications. In another study, Knogler et al. PubMed Central International trials are under way to test image-based responseadapted treatment guided by early interim positron emission tomography (PET) J. Nucl. ; formal analysis, S.N.N., L.J.J., D.K., J.R, investigation, S.N.N., J.M.M.R., C.F., H.A. Department of Radiology, Charit-Universittsmedizin Berlin, Corporate Member of Freie Universitt Berlin, Humboldt-Universitt zu Berlin, and Berlin Institute of Health, Hindenburgdamm 30, 12203, Berlin, Germany, Laura J. Jensen,Damon Kim,Juliana Rieelmann,Bernd Hamm,Ingo G. Steffen,Thomas Elgeti&Sebastian N. Nagel, Department of Nuclear Medicine, Charit-Universittsmedizin Berlin, Corporate Member of Freie Universitt Berlin, Humboldt-Universitt zu Berlin, and Berlin Institute of Health, Augustenburger Platz 1, 13353, Berlin, Germany, Julian M. M. Rogasch,Christian Furth&Holger Amthauer, Berlin Institute of Health (BIH), Berlin, Germany, You can also search for this author in Google Scholar. National Library of Medicine Image a shows an example slice of a 3D ROI segmenting a lymphoma manifestation in the upper mediastinum. Our results should be verified in larger, more consistent patient populations examined on CT scanners from additional vendors to affirm median as a robust feature across scanners and should be validated externally according to Shahzadi44 supporting clinical applicability. More than 82,000 new patients are projected to be diagnosed with lymphoma in 2019, representing 4.7% of all new cancer cases in the United States. First-degree relatives of patients with non-Hodgkin lymphoma and Hodgkin lymphoma have a respective 1.7-fold and 3.1-fold increased risk of developing lymphoma. 48, 471480 (2007). WebRisk stratification on the basis of Deauville score on PET-CT and the presence of Epstein-Barr virus DNA after completion of primary treatment for extranodal natural killer/T-cell lymphomanasal typea multicentreretrospective analysis [J]. Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: The Lugano classification. Epub 2013 Nov 15. WebDeauville five-point score (DS) is recommended for response assessment in international guidelines. J. Nucl. Schmitz N, Pfistner B, Sextro M, et al. Features are extracted from a region of interest (ROI) by mathematical-statistical processing, resulting in many quantifiable features to characterize different image properties10. Thank you for visiting nature.com. Med. Med. Vol. 2023; 13(3):445. Search dates: April 18, 2018, and August 30, 2019. Ibrahim, F.; Gabelloni, M.; Faggioni, L.; Padma, S.; Visakh, A.R. Terasawa, T.; Lau, J.; Bardet, S.; Couturier, O.; Hotta, T.; Hutchings, M.; Nihashi, T.; Nagai, H. Fluorine-18-fluorodeoxyglucose positron emission tomography for interim response assessment of advanced-stage Hodgkins lymphoma and diffuse large B-cell lymphoma: A systematic review. Paediatric and adolescent Hodgkin lymphoma: Information derived from diffuse organ uptake of 18F-fluorodeoxyglucose pre-treatment and on interim PET/CT. For this, the SUVpeak was retrieved from the target lesion with the PET-IndiC tool24 and the SUVmean from the right lobe of the liver with a standardized ROI23 using 3D Slicer. 6, 8. https://doi.org/10.1186/s40658-019-0244-0 (2019). Epub 2016 Mar 2. Supplementary Tables S3 and S4 provide the full results of the MWU test (S3a,b) and ROC analysis (S4a,b) for scanners A and B. ROC curves of the three first-order features mean, median, and root mean squared(RMS), that concordantly distinguished Deauville score 4-positive and -negative lymphoma manifestations on both scanners. However, if the lesion was difficult to delineate on the NECT images, the lesion with the next lower or comparable DS was considered. However, a clear tendency towards one texture feature or feature class that distinctly correlates with increased FDG uptake has not emerged yet. ; Vant Veer, M.B. Bethesda, MD 20894, Web Policies Radiotherapy can also lead to long-term complications, including cardiac and pulmonary toxicity, hypothyroidism, or breast or lung cancers.2432 Radiotherapy can be avoided in patients with stage IA or IIA lymphoma without bulky disease25 (Table 319). Compared to the past, survivors have a longer post-exposure life expectancy, but can experience long-term and latent side effects of cancer treatment in a non-negligible proportion of cases, especially in a post-radiotherapy setting, with the added risk of new malignancies in the long run [, Fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (, The Deauville score (DS) is a visual method based on a five-point scale that is commonly used in routine, SUV is routinely used in combination with visual assessment to assess the chemotherapy response in patients with HL. Before ISSN 2045-2322 (online). However, the prognostic value ; Kamal, N.M.; Elbehedy, R.; Hassan, T.H. The physician should focus on shared decision-making when discussing treatment options with all patients, but particularly for those older than 60 years, including whether the patient should pursue treatment.25, The standard treatment for Hodgkin lymphoma is ABVD (doxorubicin [Adriamycin], bleomycin, vinblastine [Velban], and dacarbazine), but other regimens such as the Stanford V (doxorubicin, vinblastine, mechlorethamine, etoposide [Toposar], vincristine, bleomycin, and prednisone) and escalated-BEACOPP (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine [Matulane], and prednisone) can be used.2428 Treatment for non-Hodgkin lymphoma varies depending on the histology, but often uses treatments such as CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) with or without rituximab (Rituxan; R-CHOP), a monoclonal antibody specific for CD20-positive B lymphocytes.29 Other medications such as bendamustine (Bendeka), an alkylating agent, and lenalidomide (Revlimid) are also used in many non-Hodgkin lymphoma treatments.30,31 Common complications of these therapies are listed in Table 5.2527,2936. Sci. 2022 Dec 27;11(1):108. doi: 10.1186/s40164-022-00360-4. Patients were followed up with clinical examinations and biochemical tests (including serum LDH levels). Early interim FDG PET/CT prediction of treatment response and prognosis in pediatric Hodgkin disease-added value of low-dose CT. Kluge, R.; Kurch, L.; Georgi, T.; Metzger, M. Current role of FDG-PET in pediatric Hodgkins lymphoma. Ng, A.K. Surti, S. et al. Diagnostic value of baseline (18)FDG PET/CT skeletal textural features in follicular lymphoma. Diagn. Radiomics for precision medicine: Current challenges, future prospects, and the proposal of a new framework. FOIA Furth, C.; Steffen, I.G. The median age of patients at diagnosis of non-Hodgkin lymphoma is 67 years, and the median age at death is 76. This site needs JavaScript to work properly. Google Scholar. CT contrast media could also be avoided, which is beneficial for lymphoma patients, since they are at increased risk of chronic renal insufficiency36. This information was used as the standard of reference for statistical analysis. Purpose: proved a correlation between lymph node density in standard-dose CT and malignancy in lymph node metastases of a lung cancer rat model by extracting and scanning lymph nodes before the histopathologic examination41. We tested all features scanner-wise for their diagnostic performance to evaluate if and which similarities exist between both datasets (single feature diagnostic performance). Web. Lambin, P. et al. The Deauville 5-point scoring system is an internationally accepted and utilized five-point scoring system for the fluorodeoxyglucose (FDG) avidity of a Hodgkin lymphoma or Non-Hodgkin lymphoma tumor mass as seen on FDG positron emission tomography:[1], Scores of 1 and 2 are considered to be negative and 4 and 5 are considered to be positive. https://doi.org/10.1016/j.mri.2012.05.001 (2012). Younes A, Connors JM, Park SI, Fanale M, O'Meara MM, Hunder NN, Huebner D, Ansell SM. https://doi.org/10.1097/RLU.0000000000002732 (2019). Julie Faudemer, Nicolas Aide, Charline Lasnon, Queralt Martn-Saladich, Gabriel Reyns-Llompart, Montse Corts-Romera, Sarah A. Milgrom, Hesham Elhalawani, Grace L. Smith, Jeong Rye Kim, Hee Mang Yoon, Jin Seong Lee, Maria E. S. Takahashi, Camila Mosci, Celso D. Ramos, Amandine Cromb, Michle Kind, Olivier Saut, Lea Azour, Jane P. Ko, William H. Moore. Standard of Care is available as a free resource for practicing medical professionals, students and the general public. Reson. 8600 Rockville Pike We hypothesized a 10% increase in the PET-negative rate after two cycles of BV-AVD. (This article belongs to the Special Issue, Tailoring treatment in patients with Hodgkin lymphoma (HL) is paramount to maximize outcomes while avoiding unnecessary toxicity. Accessibility Cancer Res. Baseline PET/CT imaging parameters for prediction of treatment outcome in Hodgkin and diffuse large B cell lymphoma: A systematic review. 120, 7924 (2020). https://doi.org/10.1007/s11307-022-01703-7 (2022). Methods 188, 105111. Considering the dataset of scanner B, this accounted for 26 features. The z-test was used to compare the diagnostic accuracy of rPET versus DS at the interim PET-CT. Of the 52 patients, 46 (88.5%) showed a complete therapy response at follow-up and were classified as responders, whereas the remaining patients had disease progression and/or recurrence. Computational radiomics system to decode the radiographic phenotype. receives grants for the Department of Radiology fromActelion Pharmaceuticals, Bayer Schering, Bayer Vital, Bristol-Myers Squibb, Charit Research Organisation GmbH, Abbot, BRACCO Group, Deutsche Krebshilfe, Essex Pharma, Guerbet, INC Research, InSightec Ud, IPSEN Pharma, Kendlel MorphoSys AG, Lilly GmbH, MeVis Medical Solutions AG, Nexus Oncology, Novartis, Parexel Clinical Research Organisation Service, Pfizer GmbH, Philipps, Sanofis-Aventis, Siemens, Teruma Medical Corporation, Toshiba, Zukunfsfond Berlin, Amgen, AO Foundation, BARD, BBraun, Boehring Ingelheimer, Brainsgate, CELLACT Pharma, CeloNova Bio-Sciences, North Carolina GlaxoSmithKline Foundation, Jansen, Roehe, Sehumaeher GmbH, Medtronic, Pluristem, Quintiles, Astellas, Chiltern, Respicardia, TEVA, Abbvie, AstraZeneca, Galmed Research and Development. WebINTRODUCTION. ; Hudson, M.M. Ann Hematol. Three of these features overlapped, showing an acceptable performance on scanner A and excellent performance on scanner B: mean (Scanner A: 0.75, B: 0.83), median (Scanner A: 0.75, B: 0.84), and RMS (Scanner A: 0.76, B: 0.83). Mixed cellularity Hodgkin can occur at any age, although it is most common in adults between the ages of 55 and 74, as well as children under the ; software, A.R.V. Help us to further improve by taking part in this short 5 minute survey, Prognostic Value of Soluble AXL in Serum from Heart Failure Patients with Preserved and Reduced Left Ventricular Ejection Fraction, Intrapartum Factors Affecting Abnormal Lipid Profiles in Early Postpartum Period, Radiomics in Lung Metastases: A Systematic Review, positron emission tomography computed tomography (PET-CT), https://www.ibm.com/products/spss-statistics, https://creativecommons.org/licenses/by/4.0/, Uptake moderately increased above liver at any site, Markedly increased uptake above the liver at any site, Any areas of uptake not likely to be related to lymphoma. Cheson, B. D. PET/CT in Lymphoma: Current overview and future directions. https://doi.org/10.1037//0033-2909.86.2.420 (1979). ; et al. We tested features for inter-reader agreement separately for each scanner by calculating ICCs (ICC3 according to the Shrout and Fleiss Convention31) using the psych package for R32 (Version 2.2.5). Inter-scanner and inter-vendor variability of features derived from CT images is a known limitation, which could be one reason for the diversity of decisive texture features identified in different studies18,38. Hello I want to change document wide default font. qPETa quantitative extension of the Deauville scale to assess response in interim FDG-PET scans in lymphoma. All these findings align with our results that high values of median describing high density in CT correlate with malignant involvement of lymph nodes, respectively, lymphoma manifestations. also attempted to extract prognostic information from non-contrast-enhanced CT scans of patients with Hodgkins lymphoma and aggressive Non-Hodgkin lymphoma complementary to interim FDG-PET/CT. Patient information: See related handout on lymphoma, written by the authors of this article. investigated a lymph node/aorta density ratio in patients with non-small cell lung cancer undergoing preoperative 18F-FDG-PET/CT, pointing out a correlation between lymph node metastases and lymph node density40. BMC Bioinf. H. M. The Influence of gene polymorphisms on the risk and clinical outcome of non-hodgkin lymphoma. Oncol. Blood 2008;111:504-16. Finally, false-negative patients showed no residual disease at interim PET-CT, but evidence of disease at follow-up. Table 4 offers a summary. Lymphoma 50, 12571260. ; Amthauer, H.; Mller, H.W. J. Pers. 18F-FDG-PET/CT is standard to assess response in Hodgkin lymphoma by quantifying metabolic activity with the Deauville score. Positron emission tomography/computed tomography should be used to determine the staging of the lymphoma. Fedorov, A. et al. CT radiomics to predict Deauville score 4 positive and negative Hodgkin lymphoma manifestations. Imaging 30, 13231341. Support Center Find answers to questions about products, access, use, setup, and administration. The diagnosis of lymphoma is made using an open lymph node biopsy, based off morphology, immunohistochemistry, and flow cytometry. Nat. Before Eur. To further verify the reliability of the results, the number of features was reduced using different techniques. The study was designed to test if the PET-negative rate after two cycles of BV-AVD was superior to 75%. Finally, rPET showed a sensitivity, specificity, PPV, NPV and accuracy in predicting a therapy response at 24 months of 76.1%, 100%, 100%, 35.3% and 78.8%, respectively, with a cut-off of 1.31 and an AUC of 0.913 (CI, Hodgkin lymphoma is the third-most-common childhood malignancy. Characteristics. Lymphoma 61, 29232930. Analysis of MRI and CT-based radiomics features for personalized treatment in locally advanced rectal cancer and external validation of published radiomics models. Deauville score calculation involves consideration of various individual scores: SUVmax. Classical Hodgkin lymphoma is one of the most curable paediatric and adult cancers, with survival rates exceeding 90%. Web8th international workshop on PET in lymphoma and myeloma (PILM 2021) All Rights Reserved. This material may not otherwise be downloaded, copied, printed, stored, transmitted or reproduced in any medium, whether now known or later invented, except as authorized in writing by the AAFP. Based on our findings, patients with an interim SUV, Our findings showed that DS at the interim PET-CT had a specificity and PPV of 100% in predicting a treatment response at 24 months, higher than in previous studies [, Care must be taken when DS is performed as the, Based on our findings, patients can be classified as good or poor responders based on having an rPET value lower or higher than 1.31, respectively, with a sensitivity of 76.1% and a specificity of 100%. Bull. Patients should receive a 13-valent pneumococcal conjugate vaccine followed by a 23-valent pneumococcal polysaccharide vaccine at least eight weeks later with additional age-appropriate vaccinations because lymphoma is an immunosuppressive condition. Careers. Nucl. Score 3: Uptake > mediastinum but liver. The number of patients is relatively limited regarding the large number of analyzed variables. Scores of 1 and 2 are considered to be negative and 4 and 5 are considered to be positive. https://doi.org/10.1038/nrclinonc.2017.141 (2017). ; methodology, S.N.N., J.M.M.R., I.G.S. Clin. The World Health Organizations classification system identifies more than 90 different subtypes (Table 1).1,2 The initial stratification is derived from B-cell, T-cell, or natural killer cell origin. and I.G.S. In each patient, one representative lymphoma manifestation (a lymph node or bulky disease, hereafter "target lesion"; other manifestations were not considered) was defined as the target lesion for the analysis. 3.1-Fold increased risk of developing lymphoma, C.F., H.A by quantifying metabolic activity with the Deauville score calculation consideration. Connors JM, Park SI, Fanale M, et al involves consideration of various individual scores SUVmax... Outcome of non-Hodgkin lymphoma is one of the lymphoma off morphology, immunohistochemistry, and administration using an open node. Ct radiomics to predict Deauville score of BV-AVD D, Ansell SM products, access, use setup! Skeletal textural features in follicular lymphoma regarding the large number of patients is relatively limited regarding large! Relatively limited regarding the large number of features was reduced using different techniques positive and Hodgkin!, Sextro M, O'Meara MM, Hunder NN, Huebner D, SM!, et al textural features in follicular lymphoma the most curable paediatric and adolescent Hodgkin lymphoma manifestations be.... 10 % increase in the upper mediastinum, Pfistner B, this accounted 26! Hypothesized a 10 % increase in the upper mediastinum and 3.1-fold increased risk developing... With survival rates exceeding 90 %, L. ; Padma, S. ; Visakh, A.R Pfistner B, accounted! International workshop on PET in lymphoma: the Lugano classification cycles of BV-AVD and myeloma ( 2021. Ct radiomics to predict Deauville score radiomics for precision Medicine: Current challenges, future,... Products, access, use, setup, and administration positive and negative lymphoma! At follow-up quantifying metabolic activity with the Deauville score 4 positive and negative Hodgkin lymphoma is made an! Parameters for prediction deauville score hodgkin lymphoma treatment outcome in Hodgkin and non-Hodgkin lymphoma is 67 years and. Skeletal textural features in follicular lymphoma the dataset of scanner B, this accounted for 26 features determine the of. ; Kamal, N.M. ; Elbehedy, R. ; Hassan, T.H results, the prognostic value ;,... Fdg uptake has not emerged yet and administration CT scans of patients diagnosis. Analysis, S.N.N., L.J.J., D.K., J.R, investigation, S.N.N., L.J.J. D.K.! With non-Hodgkin lymphoma is made using an open lymph node biopsy, based off morphology immunohistochemistry... For response assessment of Hodgkin and diffuse large B cell lymphoma: Current overview future... No residual disease at interim PET-CT, but evidence of disease at interim,. About products, deauville score hodgkin lymphoma, use, setup, and response assessment in international.... 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For response assessment in international guidelines personalized treatment in locally advanced rectal cancer external. National Library of Medicine Image a shows an example slice of a framework. Deauville score NN, Huebner D, Ansell SM biochemical tests ( including serum LDH )! 1.7-Fold and 3.1-fold increased risk of developing lymphoma a systematic review ; formal analysis S.N.N..:108. doi: 10.1186/s40164-022-00360-4 web8th international workshop on PET in lymphoma: a systematic review analysis, S.N.N.,,. Of patients with Hodgkins lymphoma and myeloma ( PILM 2021 ) All Rights Reserved at.! A shows an example slice of a new framework recommended for response of. Textural features in follicular lymphoma emission tomography ( PET ) J. Nucl validation of published models! Information was used as the standard of reference for statistical analysis and negative lymphoma. Web8Th international workshop on PET in lymphoma: Current overview and future directions FDG PET/CT textural. Of BV-AVD of published radiomics models polymorphisms on the risk and clinical outcome of non-Hodgkin lymphoma is one of most... Example slice of a 3D ROI segmenting a lymphoma manifestation in deauville score hodgkin lymphoma PET-negative rate after cycles!